纳米骨材料的研究现状及临床应用☆

Abstract

BACKGROUND: To understand mechanism, biological property and morphological component of nanometer bone material and discuss present status and applied prospect.

DATA SOURCES: A computer-based online search of Medline database was undertaken to identify articles about mechanism, biological property and morphological component of nanometer bone material in English from January 1966 to February 2006, and the key works were novel bioactive materials and bone tissue engineering; meanwhile, Chinese relevant articles were retrieved in Chinese in Tsinghua database from January 2001 to October 2004, and the key words were nanometer bone and clinical application.

STUDY SELECTION: Articles in disposal group and control group were retrieved firstly. Those obviously non-random and repetitive researches were excluded. Full text of the rest articles was looked up finally.

DATA EXTRACTION: There were 124 articles about mechanism, biological property and morphological component of nanometer bone material. Among them, 27 experiments or clinical researches were included.

DATA SYNTHESIS: Nanometer bone has favorable conductibility and induction of bone; meanwhile, it is characterized by human-like grading structure and multi-well structure of rangu, favorable biocompatibility and stable biodegradation. Nanometer bone material also can be used in confluence of vertebral body, the buccal surgery fields, the gene therapy of uncompleted osteogenesis, rheumatic arthritis (RA) and malignant tumor. Nanometer bone material is tendency to perfection through improvement of technology.

CONCLUSION: Nanometer bone material with many particular properties overcomes many difficulties and achieves a satisfactory effect at clinical pilot phase.

Department of Orthopaedics, First Hospital Affiliated to China Medical University, Shenyang 110001, Liaoning Province, China

Huang Tao☆, Doctor, Attending physician, Department of Orthopaedics, First Hospital Affiliated to China Medical University, Shenyang 110001, Liaoning Province, China
ht72724@126.com

Received: 2006-05-12
Accepted: 2006-07-17
(06-50-4-3275/H)

Huang T, Lü G.Research and clinical application of nanometer bone material.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu 2007;11(1):194-196

[www.zglckf.om/zglckf/ejournal/upfiles/07-1/1k-194(ps).pdf]

摘要
目的：了解纳米骨材料的作用机制、生物学特性、形态成分等，对其现状及应用前景加以论述。
资料来源：检索Medline 1966－01/2006－02关于纳米骨材料的作用机制、生物学特性、形态成分的文
章,检索词“novel bioactive materials,bone tissue engineering”,并限定文章语言种类为英语。同时检索清华全文数据库2001－01/2004－10关于纳米骨材料的作用机制、生物学特性、形态成分的文章,限定文章语言种类为中文,检索词纳米骨，临床应用。
资料选择：对资料进行初审，选取包括处理组和对照组的文献，筛除明显不随机的和重复性研究，对剩余的文献开始查找全文。
资料提炼：共收集到124篇关于纳米骨材料的作用机制、生物学特性、形态成分的文章，27个实验或临床研究符合纳入标准。
资料综合：纳米骨具有良好的骨传导性和骨诱导性，同时其区别于传统人工骨材料之处在于具有类似人然骨的分级结构和多孔结构、良好的生物相容性，稳定的生物可降解性。纳米骨材料在临床应用方面包括用于椎体融合、口腔外科领域和基因治疗骨生成不全、风湿性关节炎及恶性肿瘤。经过改进或技术处理的纳米骨材料不断出现并日趋完美。
结论：纳米骨材料以其不可比拟的性能，克服了诸多不足并在临床试用阶段取得了成功。
关键词：骨代用品；骨生成；综述文献；羟基磷灰石类

黄 涛，吕 刚
中国医科大学附属第一医院骨科，辽宁省沈阳市 110001
黄 涛☆，男，1972年生，四川省安岳县人，汉族，2005年中国医科大学毕业,博士,主治医师，主要从事骨组织工程临床应用的研究。

中图分类号:R496.1 文献标识码:A 文章编号：1673-8225(2007)01-00194-03
黄涛，吕刚.纳米骨材料的研究现状及临床应用[J].中国组织工程研究与临床康复，2007，11(1):194-196
[www.zglckf.com/zglckf/ejournal/upfiles/07-1/1k-194(ps).pdf]