Space variation of C4-5 bone intervertebral foramina resulting from different loadings

Abstract

AIM： To analyze the pathologic variation of the space of bone intervertebral foramina between C4 and C5 (C4－5) under the different loadings.

METHODS： The experiment was accomplished in the Affiliated Hospital of Xiangnan University between January and May in 2006. Ten fresh adult corpse cervical samples were adopted (volunteer donation or relatives' consent) with intact cervical disc, ligament and the facet joint capsule ranged from C3 to T1 segment. All specimens were divided into 4 groups: C4－5 having undergone cervical intervertebral discectomy (B group) or no cervical intervertebral discectomy (A group) or cervical disc prosthesis replacement (C Group) or anterior cervical discectomy and fusion using bone graft and plate fixation (D Group). The pathologic variational regulation of length diameter, superior width, inferior width, and the space of C4－5 bone intervertebral foramina was analyzed under the different conditions of C4－5 through different graded-loading-forces (25, 50, 75, 100, 125, 150 N, 5 mm/min) in axial on adult corpse cervical spine samples.

RESULT: The space of bone intervertebral foramina between C4 and C5 in B group was significant statistically decreased compared with A, C and D groups [25 N loading: (57.26±17.65), (65.81±16.83), (75.37±17.75), (66.21±16.50) mm2, P < 0.05; 50 N loading: (57.13±17.64), (65.72±16.85), (75.35±17.75), (66.11±16.46) mm2, P < 0.05; 75 N loading: (55.26±17.66), (64.80±16.85), (73.32±17.74), (65.21±16.48) mm2, P < 0.05; 100 N loading: (53.22±17.66), (63.81±16.83), (71.35±17.76), (65.27±16.46) mm2, P < 0.05; 125 N loading: (51.25±17.64), (62.82±16.83), (69.25±17.74), (65.25±16.43) mm2, P < 0.05; 150 N loading: (49.16±17.65), (61.84±16.86), (67.15±17.73), (65.24±16.42) mm2, P < 0.05]. The space of C4－5 bone intervertebral foramina was also higher in C group than in D group (P < 0.05).

CONCLUSION: There has been an obvious decrease in the space of bone intervertebral foramina under the condition of C4－5 having undergone cervical intervertebral discectomy.

Wang X, Liu WH, Meng YB, Wang QB.Space variation of C4－5 bone intervertebral foramina resulting from different loadings.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu 2007;11(13):2466-2469(China) [www.zglckf.com/zglckf/ejournal/upfiles/07-13/13k-2466(ps).pdf]

摘要
目的：分析不同载荷对C4～5椎间孔孔径变化的影响。
方法：实验于2006－01/2006－05在湘南学院附属医院进行。成人新鲜尸体颈椎标本10具（自愿捐献或家属同意），节段包括C3~T1，剔除肌肉组织，保留椎间盘、韧带和关节囊结构的完整。分别测量椎间盘完整、椎间盘髓核摘除、颈人工椎间盘置换和前路钢板植骨内固定4种状态下，加压速度为5 mm/min时，25，50，75，100，125和150 N的分级轴向载荷加载于标本时C4～5上下径、上前后径、下前后径以及椎间孔面积的变化。
结果：①轴向加载25 N时，C4～5椎间孔面积椎间盘髓核摘除标本小于完整椎间盘、颈人工椎间盘置换和前路钢板植骨内固定标本[（57.26±17.65），（65.81±16.83），（75.37±17.75），（66.21±16.50）mm2，P < 0.05]；颈人工椎间盘置换标本大于颈椎植骨融合钢板内固定标本 (P < 0.05)。②轴向加载50 N时，C4～5椎间孔面积椎间盘髓核摘除标本小于其他3组[（57.13±17.64），（65.72±16.85），（75.35±17.75），（66.11±16.46）mm2，P < 0.05]；颈人工椎间盘置换标本大于颈椎植骨融合钢板内固定标本 (P < 0.05)。③轴向加载75 N时，上下径：C4～5椎间孔面积椎间盘髓核摘除标本小于其他3组[（55.26±17.66），（64.80±16.85），（73.32±17.74），（65.21±16.48）mm2，P < 0.05]；颈人工椎间盘置换标本大于颈椎植骨融合钢板内固定标本 (P < 0.05)。④轴向加载100 N时，上下径：C4～5椎间孔面积椎间盘髓核摘除标本小于其他3组[（53.22±17.66），（63.81±16.83），（71.35±17.76），（65.27±16.46）mm2，P < 0.05]。 ⑤轴向加载125 N时，C4～5椎间孔面积椎间盘髓核摘除标本小于其他3组[（51.25±17.64），（62.82±16.83），（69.25±17.74），（65.25±16.43）mm2，P < 0.05]。⑥椎间孔面积：轴向加载150 N时，C4～5椎间孔面积椎间盘髓核摘除标本小于其他3组[（49.16±17.65），（61.84±16.86），（67.15±17.73），（65.24±16.42）mm2，P < 0.05]
结论：颈椎间盘髓核摘除后C4～5椎间孔有效空间明显减少。
关键词：颈椎；椎间孔；椎间盘摘除；颈人工椎间盘；前路钢板；康复工程

王晓，刘文和，蒙艳斌，王岐本.不同载荷作用下C4～5椎间孔孔径的变化 [J].中国组织工程研究与临床康复，2007，11(13):2466-2469
[www.zglckf.com/zglckf/ejournal/upfiles/07-13/13k-2466(ps).pdf]