课题背景：强迫性障碍执行功能的研究结果各异。造成这种差异的可能性很多：一是目前执行功能内容的具体范畴复杂，研究对执行功能的定义不同，没有细化分类研究；二是研究执行功能所采用的方法还不统一；三是强迫性障碍本身有十分复杂的临床相，不同的临床特点和症状内容类型等因素都可能对执行功能有着影响。针对以上可能，本文采用五个层面理论来描述执行功能，并尝试从不同的强迫症状分析与执行功能的相关性，探讨症状和执行功能的相关性。

重要的概念：执行功能是一种为完成所赋予的目标而去计划、排序、监控自己行为的能力，同时也能在改变任务要求下去灵活调整认知的适应性。目前认为执行功能可能与强迫的临床特征、干预等有关。

同行评价：已有的研究提示强迫症的执行功能损害的程度和临床症状内容(主要分为强迫思维和强迫行为两大类)相关，本文进一步从症状内容(根据MMOCI量表细分为20个条目)与执行功能损害层面进行相关分析，并得出阳性结果，在方法上有创新性。如果能够用实验心理方法对强迫症执行功能的心理过程深入研究，则有可能取得更大突破。

摘要
背景：以往对不同强迫症状类型的执行功能比较的报道较多，但是对具体症状内容的相关性研究较少。
目的：探讨强迫性障碍患者的执行功能与症状内容的相关性。
设计、时间及地点：病例观察于2004-11/2005-11在北京大学精神卫生研究所完成。
对象：强迫性障碍患者60例，年龄18~40岁，智力正常，无重大躯体疾病和其他精神障碍。
方法：所有受试者采用威斯康星卡片分类测验和连线测验评估其模式转换层面功能，河内塔测验评估其计划层面功能，Rey 复杂图和数字倒背实验评估其工作记忆层面功能、Stroop测验评估其抑制层面功能，言语流畅性测验评估其流利性层面功能，在应用各种神经心理学测验评定执行功能的同时使用含有20个条目的Maudsley强迫症状问卷修订版（MMOCI）评定强迫症状的具体内容和程度。
主要观察指标：应用SPSS 10.0统计软件进行Pearson和Spearsman相关分析，评估各执行功能层面与强迫性障碍症状内容的相关性。
结果：60例均进入结果分析。①模式转换层面和条目1，5，12，15，16，17，19相关（r＝-0.43~0.31），条目内容主要是强迫检查、强迫清洗和需要患者控制时间进行的动作。②计划层面和条目4，5，7，8，20相关（r＝-0.29~0.38），条目内容主要是反应强迫思维。③工作记忆层面和条目10相关（r＝0.27），条目内容是工作内容。④抑制层面和条目3，9，15，18相关（r＝-0.32~0.35），条目内容主要是强迫行为。⑤流利性和条目2，5相关（r＝-0.36，0.35），条目内容主要是强迫行为。
结论：症状内容表现与执行功能损害层面可能有一定的相关性，可以尝试根据症状内容推测患者可能的执行功能和社会功能状况。
关键词：执行功能；强迫性障碍；医学工程学

闫俊，王玉凤，崔玉华.应用计算机软件及Pearson、Spearsman相关分析评估各执行功能层面与强迫性障碍症状内容的相关性[J].中国组织工程研究与临床康复，2008，12(22):4257-4260
[www.zglckf.com/zglckf/ejournal/upfiles/08-22/22k-4257(ps).pdf]

Association between executive function and symptoms of obsessive-compulsive disorder assessed by Pearson and Spearsman analysis with computer software

Abstract
BACKGROUND: Previously, there are many reports concerning the comparison of executive function in varied obsessive-compulsive disorder (OCD), but their correlation with symptoms is seldom investigated.
OBJECTIVE: To study the relation between executive function and obsessive-compulsive symptoms in OCD patients.
DESIGN, TIME AND SETTING: A case observation was carried out in the Institute of Mental Health, Peking University from November 2004 to November 2005.
PARTICIPANTS: Sixty OCD patients aged 18-40 years, normal intelligence, without severe somatic diseases or other mental diseases, were enrolled in this study.
METHODS: All cases finished a series of neuropsychological tests. Wisconsin card sorting test, Trail making test, Tower of Hanoi, Rey Osterrieth Complex Figure, Stroop test and Word fluency test were used to evaluate the functions of set shifting, planning, working memory, inhibition and fluency separately. They were also assessed by modified Maudsley obsessive-compulsive disorder inventory, which was a 20-item scale.
MAIN OUTCOME MEASURES: SPSS 10.0 software was used to analyze the relation between executive function and symptom in OCD patients with Pearson and Spearsman analysis.
RESULTS: Sixty patients were all involved in the result analysis. Set shifting was correlated with items 1, 5, 12, 15, 16, 17 and 19 (r=-0.43 to 0.31) that showed the compulsive checking, compulsive washing and action needing time control. Planning was correlated with items 4, 5, 7, 8 and 20 (r＝-0.29 to 0.38) that chiefly showed the reaction thought. Working memory was correlated with item 10 (r＝0.27) that chiefly showed working. Inhibition was correlated with items 3, 9, 15 and 18 (r＝-0.32 to 0.35) that was the compulsive action. Fluency was correlated with items 2 and 5 (r＝-0.36, 0.35) that was the compulsive thought.
CONCLUSION: The OCD symptoms are possibly correlated with executive function, it is an attempt to suppose the executive function and social function of the patients according to the symptoms..

Yan J, Wang YF, Cui YH.Association between executive function and symptoms of obsessive-compulsive disorder assessed by Pearson and Spearsman analysis with computer software.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu 2008;12(22):4257-4260 [www.zglckf.com/zglckf/ejournal/upfiles/08-22/22k-4257(ps).pdf]