课题背景：课题为系列研究，研究成果包括：应用磁性生物陶瓷制作人工椎体并进行了生物力学试验，然后又用山羊作为试验动物进行了大动物试验,同时应用葡聚糖磁性毫微粒进行了磁性生物陶瓷人工椎体结合磁性毫微粒靶向治疗椎骨肿瘤的试验研究。

应用要点：目前文献所报道的胸腰椎脊柱前路器械多数固定在椎体的外侧，严格地讲属于椎体前外侧前外侧器械；对前外侧器械的生物力学研究发现了前外侧固定双侧固定不平衡的特点，这也就形成了导致松动的原因。最为重要的是这样的设计与人体结构双侧对称，功能双侧平衡的基本特点相距甚远，所以许多学者主张椎体正前方器械固定，克服前外侧固定的缺点。这也是课题设计脊柱前路解剖型固定钢板最基本的出发点。

同行评价：实验针对当前脊柱外科临床中的关键问题，立题、设计、方法均较严谨，结果可靠，结论具有较好的参考价值。

摘要
目的：基于胸腰椎解剖学的研究，设计制作了胸腰椎脊柱前路解剖型固定钢板以及生物陶瓷人工椎体，并对应用脊柱前路解剖型固定钢板，Kaneda装置以及生物陶瓷人工椎体等技术重建椎体的动物脊柱标本进行了生物力学测试比较。
方法：实验于2001-10/2002-06在华中科技大学力学系国家重点试验室完成。选取正常成年新鲜牛脊柱标本40具，由华中科技大学力学系试验室提供, 分为正常组，生物陶瓷人工椎体组，脊柱前路解剖型固定钢板加植骨组，Kaneda装置加植骨组，单纯植骨不加任何外固定组。应用与华中科技大学力学系联合研制的生物力学测试系统，采用动态加载，应用传感器动态记录方式，对各组牛脊柱标本进行三维六度的测试分析。
结果：①单纯植骨不加任何外固定组在各个方向均最不稳定。②脊柱前路解剖型固定钢板在前屈，后伸方向明显较Kaneda装置稳定。③在Kaneda装置的对侧即右侧：脊柱前路解剖型固定钢板在右旋，右弯方向与Kaneda装置固定效果相当，甚至稍强。④在Kaneda装置的固定侧即左侧，脊柱解剖型固定钢板的稳定性稍弱于Kaneda装置。⑤生物陶瓷人工椎体的固定效果各个方向均较为理想，明显地高于Kaneda装置固定、脊柱前路解剖型钢板的固定，与正常脊柱相当。
结论：应用生物陶瓷人工椎体以及脊柱前路解剖型钢板重建椎体具有良好的生物力学稳定性。
关键词：人工椎体；椎体重建；脊柱前路解剖型钢板；生物陶瓷；生物力学；脊柱植入体

娄朝晖，陈安民，陈建桥，匡建，孙淑珍，郭风劲,易成腊.生物陶瓷人工椎体以及脊柱前路解剖型钢板重建椎体的生物力学评价[J].中国组织工程研究与临床康复，2008，12(9):1605-1608
[www.zglckf.com/zglckf/ejournal/upfiles/08-9/9k-1605(ps).pdf]

Biomechanical assessment of a vertebral body reconstructed using artificial bioceramic vertebral body and anterior anatomical vertebral plate

Abstract
AIM: Based on thoracolumbar anatomy, we designed and developed anterior anatomical vertebral plate and bioceramic artificial vertebral body, and performed the biomechanics test in the calf spines reconstructed using anterior anatomical vertebral plate, Kaneda device, and artificial bioceramic vertebral body.
METHODS: The experiment was performed at the State Key Laboratory, Department of Mechanics, Huazhong University of Science and Technology from October 2001 to June 2002. Forty fresh calf spines (L1-L5), provided by the laboratory of Huazhong University of Science and Technology, were divided into normal group, artificial bioceramic vertebral body group, anterior anatomical vertebral plate fixation and bone graft group, Kaneda device fixation plus bone graft group, and bone graft alone group. The vertebral specimens were subjected to nondestructive biomechanical tests performed using a three-dimensional biomechanics measurment system (designed with Huazhong University of Science and Technology).
RESULTS: ①The bone graft group was unstable at each direction. ②The anterior anatomical vertebral plate was better than Kaneda device when the spine was forward bended or backward extended. ③The anterior anatomical vertebral plate was slightly better than Kaneda device when the spine was right rotated or bended. ④The stability of Kaneda device was better than the anterior anatomical vertebral plate in the left side of Kaneda device. ⑤The stability of artificial bioceramic vertebral body was the best at each direction, and significantly better than Kaneda device and anterior anatomical vertebral plate lateral, but similar to normal spine.
CONCLUSION: The artificial bioceramic vertebral body and anterior anatomical vertebral plate can construct the stability of spine.

Lou ZH, Chen AM, Chen JQ, Kuang J, Sun SZ, Guo FJ, Yi CL.Biomechanical assessment of a vertebral body reconstructed using artificial bioceramic vertebral body and anterior anatomical vertebral plate. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu 2008;12(9):1605-1608(China) [www.zglckf.com/zglckf/ejournal/upfiles/08-9/9k-1605(ps).pdf]