摘要
目的：支架置入宿主体内宿主所发生的变化与置入预期效果有何关系？文章观察了急性心肌梗死患者冠状动脉内支架置入前后宿主血清炎症因子的变化，并分析与支架置入后再狭窄的关系。
方法：回顾性分析沈阳市第一人民医院心内科2004-01/2006-12应用支架置入治疗急性心肌梗死患者106例，其中男61例,女45例,年龄35~79岁。均符合美国心脏病学学会/美国心脏协会(ACC /AHA)关于冠心病诊断标准。75例置入Cypher支架。31例置入Firebird支架。患者对治疗知情同意。所有患者于支架置入前、支架置入后48 h和支架置入后6个月抽取空腹静脉血,检测血清白细胞介素18，白细胞介素10，C-反应蛋白，肿瘤坏死因子α含量。
结果：106例患者均进入结果分析。①支架置入后6个月冠状动脉造影显示36例患者发生了再狭窄,另70例患者没发生再狭窄。②置入后再狭窄患者血清白细胞介素10、白细胞介素18、肿瘤坏死因子α和C-反应蛋白含量随着支架置入时间的延长逐渐升高（P < 0.01），且明显高于置入后无再狭窄患者（P < 0.01）。
结论：急性心肌梗死患者冠状动脉内支架置入后炎症因子含量升高，在支架置入后出现再狭窄的患者中更明显。
关键词：覆膜支架；支架置入；急性心肌梗死；白细胞介素18；白细胞介素10；C-反应蛋白；肿瘤坏死因子α

张全生.覆膜支架置入前后宿主血清炎症因子的变化[J].中国组织工程研究与临床康复，2008，12(9):1629-1931
[www.zglckf.com/zglckf/ejournal/upfiles/08-9/9k-1629(ps).pdf]

Changes of inflammatory factor in serum after stent implantation

Abstract
AIM: What is the correlation between in vivo change of the host and expected effect after stent implantation? This study observes changes of inflammatory factor in serum of patients with acute myocardial infarction (AMI) after stent implantation, so as to analyze its correlation with restenosis after implantation.
METHODS: A retrospective analysis was conducted among 106 AMI patients, who were admitted in Department of Cardiology, Shenyang No.1 People's Hospital from January 2004 to December 2006, including 61 males and 45 females, aged 35-79 years. AMI was diagnosed according to the standard set by American College of Cardiology/American Heart Association. The stent implanted into the patients consisted of 2 types: Cypher stent in 75 cases and Firebird stent in 31 cases. Informed contents were obtained from all the patients. Contents of interleukin-18, interleukin-10, C-reactive protein, and tumor necrosis factor-α in serum of fasting venous blood were determined before implantation, 48 hours and 6 months after implantation.
RESULTS: All the 106 patients were involved in the result analysis.①According to the coronary angiography 6 months after implantation, restenosis occurred in 36 patients, and did not occur in 70 patients.②Contents of interleukin-18, interleukin-10, C-reactive protein, and tumor necrosis factor-α in serum of patients with restenosis increased gradually with postoperative time prolonging (P < 0.01), and were higher significantly than those with the absence of restenosis (P < 0.01).
CONCLUSION: Inflammatory factor content in AMI patients increases after the coronary artery stent implantation, especially in patients with coronary restenosis after implantation.

Zhang QS.Changes of inflammatory factor in serum after stent implantation.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu 2008;12(9):1629-1631(China) [www.zglckf.com/zglckf/ejournal/upfiles/08-9/9k-1629(ps).pdf]