摘要
学术背景：现阶段国内外学者研究方向主要集中于对假体表面进行一定的处理，提高假体－骨界面的骨整合率是解决临床假体置入后松动并发症的瓶颈。
目的：通过对人工假体修饰3个阶段的演变进行综述。
检索策略：由第一作者应用计算机检索Pubmed数据库1995-01/2007-12的相关文献，检索词“Prostheses and Implants，Osseointegration，Tissue Engineering，interface”，并限定文章语言种类为English。同时计算机检索中国期刊全文数据库2003-01/2006-12的相关文献，检索词“人工假体，骨整合，组织工程，界面”，并限定文章语言种类为中文。共检索到154篇文献，对资料进行初审，纳入标准：①文章内容应与假体修饰方法及其对界面骨整合影响密切相关。②选择近期发表的文章。排除标准：筛除明显重复、时间久远及综述性文章。
文献评价：主要是通过对假体修饰方法及其对界面骨整合影响方面的文献进行汇总分析。所选用的30篇文献均为临床或基础实验研究。
资料综合：①物理修饰是指应用物理方式改变种植体表面物理特性，从而增加细胞黏附的方法。包括假体表面几何性质修饰、电荷修饰、预湿修饰3种，几何性质修饰包括喷沙、酸蚀、激光处理种植体表面、电火花加工等多种方法。②化学修饰是指通过改变载体表面的化学特性，使之产生与细胞表面分子之间的特异相互作用，不仅作用于细胞表面性质，而且会引起细胞内部结构和功能密切相关的变化。其主要研究内容包括两个方面，其一是提高种植体的表面能，另一种则在种植体表面形成生物活性物质涂层。③生物修饰主要是采用一些生物学的方法增加界面骨整合率。生物修饰主要包括贴壁因子预涂和细胞因子修饰。
结论：虽然近年来对假体-骨界面的研究日益成熟，但很多微观的机制还没有研究清楚，比如假体周围细胞的具体生物学行为及其影响因素，影响假体-骨界面骨整合率的因素，随着对假体-骨界面研究的深化及各种新理论新学说的提出，必将为临床提供一种有效，经济的预防假体松动的方法。
关键词：人工假体；骨整合；组织工程；界面；研究进展

殷晗,付志厚.人工假体材料修饰方法的理论与实践[J].中国组织工程研究与临床康复，2008，12(9):1725-1728
[www.zglckf.com/zglckf/ejournal/upfiles/08-9/9k-1725(ps).pdf]

Theory and practice of modification methods of prostheses

Abstract
BACKGROUND: Most of the studies focus on the disposal of prostheses recently. Raising the osseointegration of the bone-prostheses interface is the key to resolve the problem of loosing after prostheses embedding.
OBJECTIVE: To summarize the recent researches on decoration of prostheses.
RETRIEVAL STRATEGY: The Pubmed Database was undertaken to identify the related articles published from January 1995 to December 2007 with the key words of "Prostheses and Implants，Osseointegration，Tissue Engineering，interface” in English. Simultaneously, China Journals Full-Text Database was searched for relevant articles published between January 2003 and December 2006 with the same key words in Chinese．Totally 154 relevant articles were retrieved. AII the literatures were screened firstly．Inclusive criteria: ①articles about the decorating method of prostheses and its influence on bone-prostheses interface, and ②articles published recently. Exclusive criteria：similar or out-of-date articles and review articles．
LITERATURE EVALUATION: This literature derives from summary and analysis of the articles about the decorating method of prostheses and its influence on bone-prostheses interface. The 30 selected articles are all clinical or empirical study
DATA SYNTHESIS: ①Physical modification refers to altering the physical characteristic of prosthesis surface to increase the cells adhesion, including geometrical property, charge and prewetting. Geometrical property contained sand blast, etching, laser disposal, electrical discharge machining and so on. ②Chemical modification refers to altering the chemical characteristic of prosthesis surface to generate interaction between it and cells molecule. The interaction can alter not only the superficial property of cells but also the internal structure and function of it. Chemical modification has two aspects; one is to elevate the surface energy of implant, another is to form bioactive compound coating of implant surface. ③Biological modification refers to augmenting the osseointegration of prosthesis surface by some biological methods. Biological modification is composed of precoating of anchoring factor and cytokine modification.
CONCLUSION: Current studies on bone-prosthesis interface are well developed, but many micro-mechanisms are unclear, such as biological behavior and influential factor of cells around the prosthesis, factors affecting the osseointegration of the bone-prosthesis interface. With the deep study on bone-prosthesis interface and the proposition of new theories, an effective method to prevent prosthesis loosing can appear.

Yin H, Fu ZH. Theory and practice of modification methods of prostheses. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu 2008;12(9):1725-1728(China) [www.zglckf.com/zglckf/ejournal/upfiles/08-9/9k-1725(ps).pdf]